The challenge is considerable, but so is the satisfaction when it succeeds: creating complex sugar molecules that play a role in biology.

Op vrijdag 4 april 2025 organiseert de werkgroep Stedengeschiedenis een bijeenkomst bij de Rijksdienst voor het Cultureel Erfgoed onder de titel ‘Archeologie en de stad’. De studiedag is gratis en voor iedereen toegankelijk.

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

Since February 1st, 2017 Célia Fonseca Guerra is appointed as professor at the LIC with a chair in applied theoretical chemistry. She will be a member of the Theoretical Chemistry group. Her research interests are related to bioinorganic chemistry and catalysis and her appointment at the LIC will strengthen…

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.

The Executive Committee consists of the following members:

Promotor: Prof.dr. E. Bouwman

This thesis studies theoretical surface chemistry within the field of heterogeneous catalysis.

Professor Hermen Overkleeft has received the esteemed Roy L. Whistler International Award in Carbohydrate Chemistry for 2024 by the International Carbohydrate Organization. The award recognises Overkleeft’s outstanding contributions to the field of carbohydrate chemistry and biochemistry.

Nathaniel Martin has been appointed professor in the field of Bioorganic Chemistry within the Faculty of Science at the Institute of Biology Leiden, starting from 1 March 2018. His research focuses on using new (bio)chemical approaches to combat infectious disease, as well as on developing new molecular…

As of July 1, Professor of Bio-organic Synthesis Hermen Overkleeft will be appointed as the Scientific Director of the Leiden Institute of Chemistry (LIC). He will succeed Jaap Brouwer, who has been managing the institute for the past twelve years. Overkleeft has been appointed for a period of four…

Andreas Bender, Assistant Professor for Medicinal Chemistry in the Medicinal Chemistry Division of the Leiden / Amsterdam Center for Drug Research, received the

Leiden chemist Roxanne Kieltyka is part of the 2018 Talented 12 list of the American Chemical Society. That was announced by the journal Chemical & Engineering News on 19 August.

The Chemistry and LST master’s programmes are both structured on an individual basis and well-embedded in the research at the faculty. Those are the main conclusions of the oral report at the end of the visit of the visitation panel on October 10th.

How do fats and enzymes in the brain contribute to multiple sclerosis? In his PhD research, Daan van der Vliet combined chemistry and neuroscience to gain new insights into how brain disorders develop.

During the 20th anniversary meeting of the Netherlands' Catalysis and Chemistry Conference, Marc Koper received the Netherlands Catalysis and Chemistry Award. ‘The ultimate candidate for the prize’, it says in one of the recommendation letters.

With Sylvestre Bonnet, Jeroen Codée and Remus Dame, the Leiden Institute of Chemistry (LIC) will be getting no less than three new professors. Bonnet will become professor in Bioinorganic Chemistry, Codée professor in Organic Chemistry and Dame professor in Molecular and Cellular Biochemistry.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Not experiments and lab coats, but computers and artificial intelligence: this year's Nobel Prize in Chemistry went to the inventors of the groundbreaking AI model, AlphaFold. This programme accurately predicts protein structures based on their genetic code—a crucial step in understanding biological…

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

The dark matter of biology: clumps of sugar molecules that, for example, form sugary webs around pathogens. We know very little about them. Wouter Remmerswaal threw all his talent into the challenge – both in the lab and as a modeller – and succeeded. He received his PhD on 12th September.

How do classroom demonstration experiments help students learn chemical reasoning? Marie-Jetta den Otter, PhD student at ICLON, researched this. She defends her thesis on 6 December.

Last year, chemists Dennis Wander and Hermen Overkleeft contributed to an important discovery about a widely used cancer drug. Their research has now been recognised as Finalist for the PNAS Cozzarelli Prize in the Biomedical Sciences class.

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Bas Verberk defended his thesis on 6 September 2016

This dissertation contains the further development of a method for linguistic-stylistic research, which provides a systematic means to interpret global impressions of a text through choices in formulation at word- and sentence level.

You can find more information on the Dutch webpage. Click on the “Nederlands” button above.

On 26 February 2020, Hans-Jan van Kralingen defended his thesis 'De ondeelbaarheid van het pand- en hypotheekrecht, deconstructie van een leerstuk'. The doctoral research was supervised by Prof.mr. W.J. Zwalve and Prof.mr. E. Koops.

This publication is in Dutch.

The dissertation focuses on the work of German philosophers Theodor W. Adorno and Max Horkheimer, founders of critical theory at the Frankfurt School. Specifically, it is a study of the “early” writings, dated between 1925 and 1940, to reconstruct the early stages of critical theory. The thesis argues…

Fish climbing trees, storks taking care of their parents… Premodern textual and visual culture presents us with a fabulous bestiary that reveals ingenious and rich reflections on the animal kingdom.

Michiel Pronk defended his thesis on 30 March 2016

This book aims to understand cultural transitions and negotiations between art and politics from 1989 to 2020 through analysis of a series of Cuban novels.

The study at hand focuses on the control of sex and youngsters through the response by authorities most notably from within criminal justice.

This work focuses on the interpretation of the archaeological remains of the Mixtec culture in Southern Mexico on the basis of the knowledge, perceptions, economy and worldview of contemporary descendant communities.

Digital edition of the correspondence between the philosopher Gerardus Johannes Petrus Josephus (Gerard) Bolland (1854-1922) and the philologist Pieter Jacob Cosijn (1840-1899), consisting of 46 letters covering the period 1879 to 1899.

The Dutch prefix ge- in historical perspective gives first of all a general account of the development of the word formation processes involving ge- in which special attention is paid to the participial ge-.

ASLU 29 Maarten E.R.G.N. Jansen, Valentina Raffa (2015)

PhD defence

A common assumption in chemistry is that the coordination number of a catalyst's surface determines the reactivity of the reaction it catalyses. Strikingly, Leiden chemists have now proven that this is not true for nature’s most simple chemical reaction: the dissociation of hydrogen. The researchers…

Es un placer y un gran honor poder contar con la participación de la Prof.dr. Margarita Mateo Palmer durante el X Congreso Internacional de la AHBx. Impartirá una conferenica plenaria bajo el título “Nombrar las cosas: avatares transhispánicos en Cuba” el Jueves 2 de Noviembre a las 9.45 en el edificio…

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

Sinds september 2010 werken Geerten Waling en Anne Heyer in het NWO project ‘The Promise of Organization’.

In the search for new medicines against diseases such as cancer, a Leiden team has developed a new workflow. This approach combines artificial intelligence (AI) with molecular modelling and is suitable for finding unknown and innovative drug structures, the researchers proved.