BACKGROUND: Explant human skin equivalents (Ex-HSEs) can be generated by placing a 4mm skin biopsy onto a dermal equivalent. The keratinocytes migrate from the biopsy onto the dermal equivalent, differentiate and form the epidermis of 1(st) generation Ex-HSEs. This is especially suitable for the expansion…

The central question in this book is whether there is a human right to family unification.

The high prevalence of pure red cell aplasia in Thailand has been associated with the sharp increase in number of recombinant human erythropoietin (rhEPO) copy products, based on a classical generic regulatory pathway, which have entered the market.

What does it actually mean to have a “human in the loop” when an AI system makes decisions about people’s lives? And is human oversight enough to prevent things from going wrong?

This is the 2017 paperback release of William Michael Schmidli's The Fate of Freedom Elsewhere, which won the 2013 Foreign Affairs Magazine Best Book of the Year.

The 2006 United Nations Convention on the Rights of Persons with Disabilities differs markedly from other forms of international human rights law: it not only protects the rights of individuals but also addresses interpersonal relations and social structures. How did the convention attain this broad…

What do scholars do when they talk about virtues (impartiality, accuracy) or vices (dogmatism, prejudice)?

In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.

The project investigates the implementation of policies and practices related to reconciliation and the strengthening of government capacity in the Odesa and Kharkiv regions of Ukraine.

On the 2nd of September Jiyan Qiao successfully defended a doctoral thesis and graduated.

In Freedom on the Offensive, William Michael Schmidli illuminates how the Reagan administration's embrace of democracy promotion was a defining development in US foreign relations in the late twentieth century.

The eighth issue of the JLGC explores the diverse and interdisciplinary research on our multifaceted relationship with animals which is currently taking place, re-examining the relationship between humans and animals, and the definitions involved.

A new Special Issue with Transnational Legal Theory edited by Jelena Belic, Matthew Canfield, Henning Lahmann, Rachel Griffin, and Barrie Sander, brings together a collective of perspectives to unpack the promise and perils of human rights as a vocabulary for governing digital platforms.

Amanda gave a talk in Vienna on the role of plant foods in human evolution, including a small teaser of the FoodWays project!

When do fire making tools appear in prehistory, and how might the use of these tools manifest in the archaeological record?

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

This is a joint PhD of the Faculty of Social and Behavioral Sciences at Leiden University and the Evolutionary Ecology Group at Antwerp University.

Have you ever stood in front of an abstract artwork and thought: “a monkey could have done that!”. As it turns out, you are wrong.

Almost three years after receiving her honorary doctorate, Dr Graça Machel returned to Leiden University. Over the course of two days she spoke with students, researchers, and other interested persons, about human rights – particularly those of women and children – in a world in which these are continually…

Human-driven environmental damage is increasingly recognised as a global crisis. Should large-scale destruction of ecosystems be considered a crime? The concept of ecocide has gained renewed attention, particularly following a proposed definition for inclusion in international criminal law, raising…

Investigating epistemic and ethical practices in medical experimentation on humans in the colonial period in Southeast Asia.

How have human-environmental entanglements changed in the Gulf of San Miguel, Darien, Panama, from the first traces human practices through to the present?

Summer School

Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…

In Humanity’s End As A New Beginning, Emeritus Professor Mineke Schipper reflects on myths about ‘the end’.

Does foreign aid promote human rights?

This summer school focuses on the emergence of sexual orientation, gender identity (SOGI) and intersex issues in different areas of international law, such as human rights law, refugee law, international economic law, and international criminal law. Details on the application for this edition are available…

Collecting as much information as possible about administering a new medicine to people can save a lot of money.

Analysis of drug adversity

NTER-SECTION is a peer-reviewed, open-access journal focusing on contributions from junior archaeological researchers at Leiden University. The journal offers an accessible platform for the publication of individual research by undergraduate and graduate students. The Editorial Board consists of PhD…

Imagining Urban Complexity introduces passionate and critical perspectives on the link between the humanities and urban studies.

The factors that dynamically sculpt the inter-regional correlation of brain patterns are poorly understood. Here, we test the hypothesis that they are shaped by the catecholaminergic neuromodulators norepinephrine and dopamine.

You can ask virtual assistant Siri about the weather, but you can’t have a real conversation with it yet. You can’t refer to anything that’s been said before, or ask the system why it says what it says. Stephan Raaijmakers, Professor by Special Appointment from TNO, hopes to change this.

This research explores how international organisations responded to the humanitarian and human rights challenges brought about by COVID-19.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

If an algorithm has to learn to understand language, simply having a lot of data doesn’t help much. Like us, a computer has to learn the language in interaction with others. Tessa Verhoef is fascinated by how this interaction works.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

In this project, researchers from computer science, law, psychology, and public administration research in practice how artificial intelligence (AI) can be leveraged to make decision-making in the security domain more effective, while also keeping it safe and accountable.

Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh

On Thursday 20 May 2021, Tania Li delivered the annual Van Vollenhoven Lecture.

Tens of thousands of soldiers and civilians have died as a result of Russia’s invasion of Ukraine in February 2022 and the continuing armed conflict. Many forms of critical infrastructure have been destroyed. Much of this devastation has been caused by weapons that utilise forms of artificial intelligence…

Two Vidi subsidies for Faculty of Archaeology.

Friday October 24th Honours students had to present their case studies on a topical issue related to Humanities. All Honours students made posters in pairs of two and had to defend their case in front of an audience at the Old Observatory. It was a tense experience, since they were being graded by…

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

Our in-house human skin equivalents contain all stratum corneum (SC) barrier lipid classes, but have a reduced level of free fatty acids (FAs), of which a part is mono-unsaturated. These differences lead to an altered SC lipid organization and thereby a reduced barrier function compared to human skin.…

uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.

Eduard Fosch-Villaronga, Associate Professor at eLaw, contributed to 'Cyber–Physical–Human Systems', a book exploring the latest developments in interactions between cyber–physical systems and humans.

The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.