Using EcoFab 2.0 devices and omics services at JGI, we will examine a plant growth promoting microbial community during interaction with different plant species.

PhD defence

Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

The Repository from the Drug Disease Model Resources (DDMoRe) consortium provides a home to a collection of computational models of disease and drug action that have been used in pharmaceutical and/or academic research. This publically available open-access resource will make it easier for researchers…

We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.

While African ground-based air quality measurements have struggled to gain national and continental footholds, satellite data, especially high-resolution measurements from the TROPOMI satellite, can provide not only continental coverage but lend new insights for regional to city-scale air quality issues…

Les Cottés is one the rare site in western Europe with occupations in sequence by the very last Neandertals and the first anatomically modern humans.

This thesis advances automata learning, a key area in computer science, with applications in software verification, biological analysis, and autonomous technologies. It explores three main themes: first, it introduces a passive learning algorithm for generating compact probabilistic models from positive…

Simulation is a formal scientific method used to develop, compare and test hypotheses (models). In the last few decades the use of simulation has increased dramatically in virtually all scientific disciplines, but is still limited in archaeology due to the technological barrier – coding skills. Starting…

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Conventional food supplies procured from rural areas are increasingly vulnerable to disruptions caused by extreme weather, geopolitical instability, and logistical bottlenecks.

Visualizing the internal structure is a crucial step in acquiring knowledge about the origin, state, and composition of cultural heritage artifacts. Among the most powerful techniques for exposing the interior of cultural heritage objects is computed tomography (CT), a technique that computationally…

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

They are only a few tens of micrometres long — far smaller than the width of a human hair – yet these robots can swim, sense, navigate and adapt in ways that look surprisingly life-like. And all this without having a brain.

Creation of a framework for environmental parameter estimation that benefits from the consistency of physics-based theory-driven models and the accuracy of the machine-learning-based data-driven models

Electrical signals travel like a wave through our neural pathways. The mathematical models for these movements could not yet properly describe all the biological properties of the nerves. PhD student Willem Schouten-Straatman changed this by improving the existing models. ‘I hope that one day we will…

The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.

Why do climate models still prioritise economic indicators over human impact? In a podcast of Land & Climate, environmental scientist Inge Schrijver highlights a critical blind spot in how climate change is assessed.

Bone research provides plenty of detailed data about the health of a person or a group. This data is not only used to reconstruct the past but also to fight disease today.

Promotor: Prof.dr. M. Schilthuizen

Erik Danen is looking at how to inhibit tumours that do not respond well to medicine – and he is making some headway. The Professor of Cancer Drug Target Discovery studies the interaction between tumour cells and their surroundings. Inaugural lecture on Friday 10 May.

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

The discussion on employability of higher education graduates has been around for several years, with more emphasis in the 21st century. Yet, universities are still challenged in the pursuit of providing work-ready graduates who can meet industry expectations.

This project investigates the well-preserved agricultural terraces of the Inn valley and the evolution of resource use in the inner Alps.

Are you dealing with an educational challenge or would like to explore innovation opportunities? We actively ideate, design, prototype, build, test real-world solutions to transform theoretical ideas into tangible solutions to enhance the educational landscape for the benefit of your students.

Meet the scientists within the LED3 community

When new features are being written into software code, errors can easily be made. This causes bugs, which leads to software appearing later and being more expensive. Michiel Helvensteijn, a PhD student from CWI and the Leiden Institute of Advanced Computer Science, studied how to prevent these kinds…

Matthijs van Leeuwen of the Leiden Institute of Advanced Computer Science develops methods to make computer models interactive. With interactive models, experts can combine information from raw data with their own knowledge to make predictions more accurate. 'In this way we hope to build models that…

Mechanisms fro drug resistance

By detecting the tiny forces between a micrometer sized magnet and the spins of hydrogen nuclei, we can do MRI with a volume resolution that is approximately 12 orders of magnitude better than a conventional MRI.  

After 41 years, Meindert Danhof, Professor of Pharmacology, is leaving the Leiden Academic Centre for Drug Research on 31 March. A symposium in his honour, prior to his farewell lecture, will show what has been achieved in this period. Danhof takes a look back on his career.

The past two years, Laura van der Knaap and Professor Karsten Lambers worked on creating open teaching materials on agent-based modeling, funded by Erasmus+ and in collaboration with Danish, Irish and Dutch partners. Programming is an important skill involved in this, which is often seen as intimidating…

Practical applications for the reconstruction of the past

Two Leiden researchers have demonstrated how mathematics can improve our healthcare. Daniel Gomon has developed a model that contributes to the quality of care in hospitals. Marta Spreafico works on an app that helps physicians make well-informed decisions about the treatment of a certain type of cancer.…

Mechanical interactions between cells and their environment play an important role in many biological processes.