This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

In this project, researchers from computer science, law, psychology, and public administration research in practice how artificial intelligence (AI) can be leveraged to make decision-making in the security domain more effective, while also keeping it safe and accountable.

The third and final participation session was held on 20 September; the evening was attended by local residents, business owners, students and other stakeholders.

The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).

How do pathogenic mycobacteria alter lipid metabolism in human cells and patients, and which disrupted pathways could be targeted for new antibiotics?

The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.

On Wednesday 13 December, Melanie Fink will defend her doctoral thesis ‘Frontex and Human Rights: Responsibility in “Multi-Actor Situations” under the ECHR and EU Public Liability Law’. The defence will take place at 10.00 hrs at the Academy Building of Leiden University, Rapenburg 73. The supervisors…

To celebrate the end of the semester the Science and Humanities Buddy Programme organised a barbecue together, which has become a small tradition. The barbecue marks the third co-organised activity between the two Programmes and helps to bring international and Dutch students together. The Buddy Programme…

Promotores: G.R. de Snoo, B. Sinsin, Co-Promotor: H.H. de Iongh

The development of the Humanities Campus is entering a new phase. On 13 June, the Municipal Council approved both the zoning plan and the visual quality plan. This means that the university can now go forward with developing the new construction and the central green square on the Doelen side of the…

The Sackler Distinguished Lecture Series on Human Rights was established at Leiden University through an endowment given by Dr. Raymond R. Sackler and his wife, Beverly, international philanthropists with a commitment to supporting scientific research. The lectures mark the annual celebration of International…

Below you will find an overview of all PRE-Classes provided by the various programmes of Leiden University. For each section, you can find a description of the content and more specific information about the requirements for participation in the Class.

Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh

On Thursday 20 May 2021, Tania Li delivered the annual Van Vollenhoven Lecture.

Because of their large surface area and immunological competence, mucosal tissues are attractive administration and target sites for vaccination.

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

It is the aim of this project to better understand how the physical properties of lipids influences the structure and overall barrier function of the skin.

Research in the Lars Jeuken group focusses on redox-active proteins and membranes enzymes, aiming to understand bacterial respiration at the molecular level for the development of antimicrobials and semi-artificial photo-synthetic cells.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

National parochialism is the tendency to cooperate more with ingroup than outgroup members. Angelo Romano, Matthias Sutter, James Liu, Toshio Yamagishi & Daniel Balliet studied national parochialism across different nations and conclude in their publication in Nature Communications that it is a ubiquitous…

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

Can the venom of snakes, scorpions and other animals be sources of new antibiotics?

Using EcoFab 2.0 devices and omics services at JGI, we will examine a plant growth promoting microbial community during interaction with different plant species.

In the emerging field of small-molecule RNA targeting, there is a growing demand for new high-throughput screening methods.

The development plans for the Humanities Campus are changing somewhat. The financial challenges at the Faculty of Humanities and the higher education cuts mean Leiden University has to reduce its spending. One consequence is the Lipsius building will not be rebuilt after demolition in 2031.

In the last weeks, ASEAN published different Statements about the human rights situation in Myanmar and the Democratic People´s Republic of Korea (DPRK).

The cellular recycling system in zebrafish is capable of eating harmful bacteria and thus resist infections such as tuberculosis and salmonellosis. That is written by Leiden biologists from the group of Annemarie Meijer. Stimulating this form of defence could be used in new treatment methods against…

While humanities once mainly involved books and archives, nowadays we can’t imagine life without AI. Next semester a new faculty-wide course will be introduced, taking you along with this development. University lecturer and course coordinator Yann Ryan tells us more about it.

On 1 October 2019 the Hazelhoff Centre for Financial law hosted its 19th guest lecture starring Paul Sharma, managing director at Alvarez & Marsal and co-head of the European Financial Industry Regulatory Advisory Services practices.

Leiden University and the Municipality of Leiden will develop new plans for an alternative Humanities Campus in the city centre. This means they will not proceed with the compulsory purchase of the De Doelen housing complex to facilitate the construction of the new Humanities Campus. The plans to demolish…

Since the emergence of humankind people have maintained social contacts and traveled widely, establishing interaction networks in which goods are traded and ideas are transmitted, increasingly on a global scale.

On 22 March 2016, Prof. Carsten Stahn spoke on prosecuting Human Trafficking as a Crime Against Humanity at a Conference on International Criminal Justice, hosted by the Collaborative Innovation Center of Judicial Civilization of Zhejing University in Hangzhou, China.

What do a linguist, an artist, a Professor of Conservation and Restoration, and a lecturer at the Leiden Institute of Advanced Computer Science have in common? They all use Artificial Intelligence. On 7 April they discussed the use of AI at Leiden’s Kijkhuis cinema.

On 24 January an interdisciplinary workshop organised by Anna Smulders, PhD candidate at the Grotius Centre for International Legal Studies, and Tarlach McGonagle, Professor of Media Law and Information Society, took place on the interaction between disinformation, emerging technologies and human rights.…

Leiden University can build an alternative Humanities Campus on its own available land at the current location in the city. This is the conclusion of a feasibility study and is what the mayor and aldermen of Leiden write in a letter to the city council.

The renovation of Cluster Zuid (Van Eyckhof-Van Wijkplaats) is the third project in the development of the Humanities Campus. The circular dismantling of Cluster Zuid has started.

Death’s Social and Material Meaning beyond the Human is edited by Jesse D. Peterson, Natashe Lemos Dekker and Philip R. Olson

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea