LUCIS organiseerde op woensdag 4 maart een speciale avond over journalistiek in Irak. Journaliste Judit Neurink en programmamaker Sakir Khader vertelden over hun ervaringen en recente werkzaamheden in het land. De avond stond onder leiding van Wendelmoet Boersema (politiek redacteur van dagblad Trou…

Kyra van der Moezel defended her thesis on 7 September 2016.

Contact information & address

As part of the NEXUS1492 project, this project will use ancient DNA techniques to shed new light on the demographic and health history of the Caribbean and the impact of European colonization on indigenous communities in the region.

This project intends to provide an integrated linguistic assessment of the hypothesised migration route of the Tocharians.

This thesis discusses the development in Proto–Indo–European, Latin and Romance of a word–formation pattern which the most adequate terminology in use dubs ‘verbal government compounds with a governing first member’; I use the shorthand ‘pickpocket compounds’.

Over poep, pies en de beerput

Een minuscuul cirkelvormig stukje DNA zorgt ervoor dat de darmbacterie Clostridioides difficile resistent raakt tegen een veelgebruikt antibioticum. Dat ontdekten wetenschappers van het Leids Universitair Medisch Centrum (LUMC) nadat artsen hen attendeerden op een patiënt met een moeilijk behandelbare…

Doctors and pharmacists should take greater account of obesity when dosing medicines. The distribution in the body and the breakdown of a medicine can vary considerably in obese patients. This is stated by clinical pharmacologist Catherijne Knibbe in the Annual Review of Pharmacology and Toxicology.

Psychological processes have a major effect on the course of a disease and the effects of medical treatment. Researchers in the field of Psychoneurobiology examine the interactions between body and mind. They investigate the effects of stress as well as the effect of placebos and nocebos, which can…

This is an Erasmus+ International Credit Mobility project of the Faculty of Social and Behavoriural Sciences with Macquarie University in Australia.

Charisma K. Lepcha (PI, Sikkim University), Pradyut Guha (co-PI, Sikkim University), Rajib Sutradhar (co-PI, Christ University Bangalore) and Erik de Maaker (Leiden University) have been awarded a two-year grant of USD 18.000 to conduct research on the impact of ‘green farming’ on the sensitive mountain…

Sasse, van Breen, Spears & Gordijn demonstrated an anger gap in response to sexism which was larger for women than for men and found evidence that expressed anger was associated with instrumental concerns.

What are the developmental pathways to social anxiety (disorder), the causal processes and maintaining factors? How do these factors interact in the development of social anxiety disorder? How can this knowledge be used to design and implement effective preventive intervention programs for youth?

In this project, we plan to combine two strands of research in speech processing: (a) the impact of prosody on speech processing and (b) the impact of musical training on speech processing. In our project we will test 8 year-old children with different degrees of musical training: (a) primary school…

Correctly interpreting the patterns of fire evidence in the archaeological record will illuminate the origin of human fire use.

Promotor: Prof.dr. J. Schaye, Co-promotor: Marcello Cacciato

This project looks at the current practices of marriage law in Indonesia. It examines the often ambiguous views different groups hold of marriage, from local villagers in Bengkulu to women’s activists in Jakarta, and how these relate to the development of national law on the one hand and local practices…

The Bakelsreeks is published on behalf of the Bakelsinstituut. The institute consists of the labour law departments of the Erasmus University Rotterdam, the University of Groningen, the social & corporate and financial law departments of Leiden University and a number of law firms, and focuses on initiating…

Through language and culture, history, anthropology, and sociology, we delve into the countries, populations, and societies of South and Southeast Asia. From this perspective, we address global issues such as migration, heritage, and colonialism.

This dissertation aims to provide a critical view of Vietnamese secondary school stakeholders’ awareness of democratic education regarding the core educational democratic values and democratic acts within either the ‘physical’ or digital learning environment.

What is the optimal design of sandy solutions for sustainable climate change adaption, from an ecological, biophysical and societal point of view?

The research project ‘The History of National Security, 1945-present', is funded by the Netherlands Organisation for Scientific Research (NWO), the Campus The Hague/Leiden University and the Netherlands Institute for Military History (NIMH). The project will run until the summer of 2013, when we hope…

In 2020, Leiden University launched its stimulated interdisciplinary programs, including one focused on regenerative medicine.

Persistent somatic symptoms are long term symptoms that lack a clear medical explanation. These symptoms have a high prevalence where most people know someone who experiences such symptoms or they experience such symptoms themselves. Symptoms can vary greatly in and between people. While one person…

The effects of many treatments are determined, to a significant degree, by factors other than the medicine or treatment itself. For example, placebo effects can be equal to the effect size of for example antidepressants or painkillers. Contributing factors are the trust placed in the doctor, the expectation…

Our team consists of the following members.

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

A new therapy for the serious Graft-versus-Host disease

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

What role do parent-child interactions play in the development, maintenance and treatment of depression in young people?

Can excessive worrying be reduced via stimulation of the vagus nerve?

PhD defence

The major aim is to determine the psychophysiological responses to stress and stress-management interventions and to examine the role of stress and stress-related psychophysiological mechanisms (e.g., cognitions, behaviors, and physiological stress responses) in both healthy and medical populations.

Our mission is to recognise and treat stress and anxiety in children as early as possible, by connecting scientific research, clinical practice and education.

Lifelong learning | “Even though we were spread across five continents, there was a strong sense of connection.”

How can we map and foster Dutch secondary teachers’ agency in inclusive education practices?

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

-

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Our everyday life consists of all sorts of spatial processes: we find our way to work, remember where we left our keys, and are able to pick up our cup of coffee. We study how the human brain processes such spatial processes. From a clinical perspective, we are interested in how acquired brain damage…

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

The research connected to this topic is related to E-health.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.