The aim of our research program is to better understand the etiology and course of mood, anxiety and stress-related disorders, such as depression and posttraumatic stress disorder (PTSD). We investigate both the transdiagnostic mechanisms underlying these disorders and work on improving the treatments…

This thesis surveys the intersection of computed tomography (CT) and machine learning (ML), treating CT as an ill-posed inverse problem shaped by object properties, imaging physics, and data limitations.

In this article, Marco Cinelli, assistant professor at Leiden University College The Hague, examines proper and improper uses of Multiple Criteria Decision Analysis (MCDA) methods in energy systems analysis.

On 21 November 2018, Lieke Kools defended her thesis 'Essays on wealth, health, and data collection'. The doctoral research was supervised by Prof. dr. K.P. Goudswaard en Prof. dr. C.L.J. Caminada.

The master’s specialisation Biodiversity and Sustainability at Leiden University provides students with a much better understanding of the biological processes which are essential for creating a sustainable society.

Research in Bio-Pharmaceutical Sciences consists of 120 European Credit Transfer System (EC) points.

In order to optimize treatment, it is necessary to closely monitor and manage the patient’s health status by means of ‘precision diagnostics, personalized prognosis and targeted therapy’. The specialisation combines the techniques and applications of these sensing (monitoring) and stimulation techniques.…

While bioinformatics methods deal with the analysis of sequence information (be it proteins or DNA), the field of cheminformatics is concerned with the analysis of small-molecule datasets.

A liveable planet. More biodiversity. And resources which are being managed wisely. At the CML, we want to make an impact with our research and education. On this website you can read what we do to achieve that.

What are the critical elements in sonic materialization of fixed media electroacoustic music and how can these parameters be classified? How would interpretation be defined in performing fixed media music? What are the creative and new ways of presenting fixed media music by incorporating all the presentation…

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

The Biomedical Metabolomics Facility Leiden (BMFL) is the core metabolomics facility of Leiden University and the Metabolomics and Analytics Centre (MAC). We offer a highly structured environment for advanced MS-based metabolomics studies and build on fully validated, state-of-the-art assays that each…

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

igraph development focused on improving the most-used interfaces, which are Python, R, and Mathematica. Additionally, the developers aim to make the library and the interfaces easier to maintain, focusing on long-term sustainability. This ensures that igraph continues to be a useful tool for network…

Here we share findings into the effectiveness of the Designing Your Life education at Leiden University. Our study indicates that DYL education has a positive effect on students’ confidence and competencies.

The Centre for Indigenous America Studies (CIAS) at Leiden University is designed to coordinate and promote the teaching and research of Indigenous languages, literatures, cultures and cultural heritage.

Promotor: M.A.G.J. Orrit

This dissertation aims at enhancing our knowledge of whether a CI provides sufficient access to auditory speech input to acquire verbal morphology by comparing outcomes of CI children to those of their normal hearing peers and to those of children with specific language impaired (SLI).

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We work on clinical problems that require further mechanistic understanding and strive for ultimate benefit to patients.

The data-driven economy allows for the collection and processing of large amounts of data. Such data can be used to optimize profits by (dynamically) differentiating prices for different consumers.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics.

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.

The presents thesis investigates the extent to which Chinese, Dutch and American speakers of English are mutually intelligible. Intelligibility of vowels, simplex consonants and consonant clusters was tested in meaningless sound sequences, as well as in words in meaningless and meaningful short sent…

This PhD project investigates how grammatical features and lexical elaboration in Fulfulde Juguureere reflect aspects of cattle culture.

The more we learn about a (neuro-)psychological or physical disorder and the related behavioral factors, the better we can not only identify them, but also treat them. It is therefore important that recent insights about (neuro-)psychological problems and related behavioral factors are incorporated…

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

This project analyses the democratic consequences of increasing decentralization and regionalization in European countries. Through an original approach that foregrounds informal political dynamics, it studies the functioning of democracy in subnational units, and investigates the effects of ever more…

Can furan-based resisn be degraded by microbial enzymes in combination with mild pre-treatment?

Supervisor: Indira Nederpelt

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

During the development of the (human) body from a single fertilized egg, organs and structures must form. The development and growth of biological forms is called morphogenesis.

Resilient future generations that will shape a healthy society.

LCN2 hosts seminars on the last Friday of each month.

Multiple Sclerosis, Parkinson’s and Alzheimer’s disease are the most common neurodegenerative disorders. Unfortunately, no effective treatments are currently available to halt the progression of these neuroinflammatory diseases [1].

Former PhD, Bachelor and Master students of the Van Exter Lab

Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…

How to make educational innovations practical for teachers

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

Institute of Environmental Sciences (CML)

Legal proceedings are often time-consuming, costly and stressful. Accessible out-of-court dispute resolution can sometimes offer a good alternative, but having access to reliable and efficient judicial proceedings remains equally important.

In dozens of study rooms, libraries and laboratories, passionate scientists – with the support of the donors of the Leiden University Fund – are working on a fundamental understanding of the world and the people around us. They make the unknown known and push the boundaries of existing fields of sci…

What are the values that Leiden University cherishes? What does the University stand for and what does it consider important?

The master’s specialisation Physics and Education at Leiden University prepares you to teach the subject of physics to secondary school students. The programme comprises a one-year physics component, followed by an education component in the second year.

The Leiden Academic Centre for Drug Research (LACDR) is a centre of excellence for multidisciplinary research on drug discovery and development.