Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

In this thesis, single-cell approaches were applied to characterize the impact of aging on the immunological B cell landscape in different models of atherosclerotic cardiovascular disease, with the goal to identify and study new B cell-associated biomarkers and therapeutic targets to halt atherosclerosis…

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

How do you engage society to stop biodiversity loss? How do you create political and social involvement to deal with climate change? And how do you balance the economic needs of industry with the negative effects of pollution? If you find these kinds of questions interesting, then this Pre-University…

Data about COVID-19 were everywhere during the pandemic, but how will all this data continue to be managed and kept open so that it is usable in the future? We spoke with Kathleen Gregory, researcher at the Centre for Science and Technology Studies (CWTS), who will study this question in a new project…

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Binnen het brede netwerk van de Universiteit Leiden neemt het instituut deel aan onderzoek binnen de volgende profileringsgebieden:

Galaxies form and evolve through close interaction with their surroundings. As a result, the heavy elements ('metals') that are synthesized in stars, are found both inside and outside galaxies.

This thesis studies operator-algebraic aspects of subproduct systems, a generalization of product systems of Hilbert spaces.

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

CT scanning of skeletal remains can tell us about how strong or weak a persons bones were and we can relate that back to diet, activity, and reproductive factors.

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

We investigate how radiation pressure can be used to influence the mechanical motion of a micro-mirror suspended from springs.

In this thesis three different topics in number theory are studied.

Promotor: S.J. Edixhoven Co-promotor: L. van Geemen, P. Parent

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

Timo Slootweg, associate professor at he department Philosophy of Law, published a chapter about Paul Scholten in

Promotor: Prof.dr. H.L.V. Linnartz

Soil biodiversity is of great importance for the maintenance of multifunctionality in terrestrial ecosystems.

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

The Low Frequency Array enables studies of low-frequency carbon radio recombination lines with unprecedented sensitivity, spectral and spatial resolution.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

Lezing

The AI Collaboration Centre focuses on delivering Smart Computing for Science & Industry. This is reflected in our long-term collaborations with industry and government partners. These partnerships keep our research grounded in real-world applicability while opening new directions within computer sc…

Promotor: Prof.dr. J.N. Kok

Search and conversational systems have become central to how people access information and perform tasks.

Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Universite Bordeaux I)

The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…

How and to what extent the historic house (re-)constructs identity through image-making in China.

Het LAK biedt verschillende schrijfcursussen aan. Maak kennis met de wereld van verhalen verzinnen. Leer de basisvaardigheden van fictie schrijven en leer als schrijver je eigen stem vinden en zet de eerste belangrijke stap van een idee naar een verhaal. Of maak kennis met poëtische technieken. De keuze…

Kunst en vrije tijd, Kunst en vrije tijd

What are the pressing issues of our time, and how can different disciplines come together to address them? Studium Generale and Leiden University College (LUC) present the Global Challenges series: events that bring together researchers from LUC and experts from other disciplines to tackle a shared…

Sinds de oprichting is LUC een college voor onderwijsontwikkeling en experimentatie. In de missie van het college wordt LUC beschreven als "een plek van innovatie op het gebied van didactiek, curriculumontwerp en studentwelzijn." Deze visie wordt toegepast via een studentgerichte benadering in het onderwijs…

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Dynamical systems describe the evolution of objects in a space over time and may be used to model physical phenomena. Due to this, much research is dedicated to understanding the mathematics of dynamical systems.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Hoe meer we leren over een (neuro-)psychologische of lichamelijke aandoening en de hieraan gerelateerde gedragsfactoren, hoe beter we deze niet alleen kunnen signaleren, maar ook behandelen. Het is dus belangrijk dat recente inzichten over (neuro-)psychologische problemen en daaraan gerelateerde gedragsfactoren…

Promotor: Peter Stevenhagen

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.