Promotores: Wim Jiskoot; Ferry Ossendorp

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Heart failure is a major health care problem with high mortality.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Het Leiden Leadership Centre is een internationale en interdisciplinaire netwerkorganisatie. In onze aanpak brengen we mensen met verschillende achtergronden en diverse perspectieven samen

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Promotor: B. van de Water

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Promotor: W. Jiskoot, Co-promotor: H.A. Every

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Promotor: A.P. IJzerman

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Preterm birth is a major contributor to neonatal morbidity and mortality and is associated with both acute complications and long-term health consequences.

Promotores: W. Jiskoot, F. Ossendorp

This thesis aims to develop model-based approaches to optimize drug dosing in patients with overweight and (morbid) obesity.

Ontdek het studentenleven bij de MSc Political Theory: Legitimiteit en Rechtvaardigheid aan Universiteit Leiden: studieverenigingen, activiteiten, academische gemeenschap en wonen in Leiden en Den Haag.

When you have decided to participate in a Summer School of Leiden University, there are some matters you need to know before arrival. Please take a few minutes to read through the information here to find out what you can do from your side to smooth the process.

Op 20 juni, gaf Freya Baetens de keynote presentatie tijdens een workshop over

Nurturing Student Creativity: Innovative Approaches to Sharing Scientific Results. Bridging Generations and Empowering Ethical Exploration in Anthropology Education

A prestigious milestone: the Class of 2025 graduates from the Advanced MSc International Relations and Diplomacy, celebrated in The Hague and Leiden’s Sweat Room.

De Young Academy Leiden wil jonge academici met elkaar verbinden. Zo eenvoudig is het immers niet in de praktijk om peers te ontmoeten buiten je vakgebied. Met inspirerende én gezellige facultaire lunches streeft de organisatie naar connectie tussen jonge wetenschappers. De meest recente, op de Faculteit…

Students Practicing Citizen Journalism

The coursework within the Science Communication and Society (SCS) specialisation prepares students for internships and a career in communication about science and health.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Hieronder vind je de antwoorden op een aantal veelgestelde vragen over toelating tot de klinische specialisaties van de Master Psychologie.

Security is key to survival for any living organism: life is full of perils and threats, both physically, environmentally, and societally. Security challenges such as terrorism, natural disasters, and cybercrime rank among the most pressing issues of our time, affecting the security and safety of millions…

Moritz Jesse has been awarded a Jean Monnet Chair by the European Commission. In his MIND-EU Project he will focus on a coherent way to teach Migration, Integration, and Non-Discrimination at Leiden Law School at bachelor and master level.

In een recent NRC-artikel wordt belicht hoe wetenschappers te maken krijgen met intimidatie en bedreigingen. Leo Lucassen, hoogleraar sociale geschiedenis in Leiden, deelt zijn ervaringen met bedreigingen naar aanleiding van zijn onderzoek en publicaties over migratie.

Op maandag 11 februari is het eerste nummer van het Journal van het LUCAS Graduate Conference 'Imagining Europe: Modern Perspectives, Perceptions and Representations' officieel online gegaan.

Publicaties die voortkomen uit het AFITE-project

Learning a programming language is challenging. Even one of the first –but crucial– concepts to learn, variables, is hard to grasp. Variables can represent different roles and functions within a code and need to be named appropriately to support code comprehension and debugging.

How should jurisdictions, both on the national and on the supra-national level, handle the interaction between public and private law where it regards the regulation of financial markets?