Promotor: A.P.IJzerman Co-promotor: A. Bender

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Hoewel bacteriën meestal niet met het blote oog te zien zijn, vormen ze de stille kracht achter veel processen in ons dagelijks leven.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

Dit boek onderzoekt de impact van het VN-Verdrag inzake de Rechten van het Kind (IVRK) op nationale en internationale rechtspraak, sinds de aanname van dit verdrag in 1989. Het boek verschaft inzicht in de functies, uitdagingen en beperkingen van het IVRK in nationale, regionale en internationale juridische…

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

High-angular-resolution observations of the circumstellar material have uncovered numerous and very diverse substructures in protoplanetary discs, raising the question of whether they are caused by forming planets or other mechanisms.

Promotietraject van de Toekomst

Promotor: S.J. Edixhoven, L.D.J. Taelman

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

In this thesis we use state-of-the-art observations and simulations to provide the best constraints to date on the HVS ejection rate and constraints on the stellar content and dynamics at the GC, including the progenitor binary populations and their star formation history.

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Hoe zetten belangenorganisaties in Nederland strategisch procederen in om politieke, maatschappelijke of juridische veranderingen te realiseren, en hoe verhoudt deze strategie zich tot andere klassieke vormen van beleidsbeïnvloeding?

The expedition commanded by Nicolas Baudin to Tenerife, Mauritius, Australia, Timor and South Africa in 1800-1804 is fully researched in regard to ornithology.

The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…

Promotor: P. T. de Zeeuw, Co-promotor: N. Neumayer; G. van de Ven

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

Promotor: Prof.dr. W.T.F. den Hollander

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

Op 11 mei 2016 ontving het Hazelhoff Centre for Financial Law Robert Pickel voor de elfde Hazelhoff Guest Lecture, getiteld ‘The Deadliest Sin of the Financial Crisis’.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

Universiteit Leiden is op 28 september met twee projecten aanwezig bij het Discovery Festival, een nachtfestival dat draait om de kick die je krijgt als je nieuwe dingen ontdekt. Antibiotica Gezocht! laat de festivalgangers meewerken in het tijdelijke laboratorium en iSPEX: ‘Meet fijnstof met je smartphone’…

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Promotor: Prof.dr. A.G.G.M. Tielens

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

Met ingang van 1 april 2018 is Erik Danen benoemd tot hoogleraar Cancer drug target discovery bij het Leiden Academic Centre for Drug Research (LACDR). Zijn vakgebied is celbiologie van kanker, waarin hij zich richt op de achterliggende mechanismen bij uitzaaiingen en resistentie voor behandelingen.

Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Op 3 december 2019 verdedigde Meda Couzens haar proefschrift 'The application of the United Nations Convention on the Rights of the Child by national courts'. Het promotieonderzoek is begeleid door promotoren prof.dr. T. Liefaard en prof.mr. J.J. Sloth-Nielsen.

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…