Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

De centrale vraag is wat Nederland kan leren van de wijze waarop deze landen de rechtshandhaving en de rechtstaat in hun overzeese gebieden hebben ingericht.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Dubbelspoor. De postuum verschenen herinneringen van professor Cees Fasseur (1938 - 2016).

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Promotor: F.S. de Boer, Co-promotor: M.M. Bonsangue

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…

In-use stocks of products can be considered as intermediaries between human needs and the physical world.

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Promotor: B. van de Water

Op 5 september verdedigde Elize de Mul het proefschrift 'Digitale dubbelgangers: identiteit in de verbeeldcultuur'. Het promotieonderzoek is begeleid door Simone van der Hof en Esther Keymolen.

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

Surface acoustic waves (SAWs) are mechanical waves that travel along the surface of a material and find many applications in modern technologies due to the ease of excitation on piezoelectric substrates via interdigital transducers (IDTs).

Op 17 oktober 2018 verdedigde Thomas Sanders zijn proefschrift 'Invordering door de overheid: de invordering van geldschulden uit herstelsancties onder de Awb'. Het promotieonderzoek is begeleid door promotoren prof. mr. T. Barkhuysen en prof. mr. M.W. Scheltema.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

Onderzoek naar het precieze taal- en spraakgedrag van sprekers.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Promotor: P.D. Grünwald

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Doordat markten in toenemende mate zijn geïnternationaliseerd, zijn (sub-)nationale toezichthouders ook steeds vaker internationaal actief. Binnen vormen van internationale netwerksamenwerking wisselen deze toezichthouders onderling informatie uit en onderhandelen ze over internationale standaarden…

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Cognitive enhancement is het gebruik van elke methode of techniek met als doel het verbeteren van cognitieve prestaties.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Op 21 februari 2019 verdedigde Ruben Zandvliet zijn proefschrift 'Trade, Investment and Labour: Interactions in International Law'. Het promotieonderzoek is begeleid door promotor prof. dr. N.J. Schrijver.

Kunst en vrije tijd, Kunst en vrije tijd

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Sommige ernstige geweldsincidenten eindigen met dodelijke afloop, andere niet. Vooral vuurwapengebruik door de dader, de aan- of afwezigheid van omstanders en het gedrag van het slachtoffer blijken cruciaal voor deze uitkomst.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Kunst en vrije tijd, Kunst en vrije tijd

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

This dissertation explores how we can make anomaly detection—identifying unusual or faulty behavior in complex systems—more trustworthy and effective, with a focus on smart manufacturing.

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The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.