Stimulerende drugs als khat en cocaïne hebben negatieve impact op dagelijkse handelingen als autorijden, werk of sociaal gedrag. Dat komt door beschadiging van controlefuncties in de hersenen. Psycholoog Manuel Ruiz draagt bij aan beter begrip en behandeling van drugsmisbruik. De Spanjaard Ruiz promoveert…

This thesis describes the design, characterization and application of dextran based crosslinked network.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Promotor: Prof.dr. M. Ubbink

Onderzoek naar oppervlaktes van vaste stoffen: het lijkt misschien niet relevant voor energieverbruik, maar toch is het zo. Marcel Rost bestudeert hoe platina-elektroden slijten. Die elektroden zijn een cruciaal onderdeel in brandstofcellen voor auto’s op waterstof. ‘We moeten de overstap maken van…

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

De Leidse promovendus Xuequan Zhou heeft een veelbelovend nieuw molecuul ontworpen dat effectief kankercellen kan bestrijden zonder hierbij ook de gezonde cellen aan te tasten. De truc: het medicijn wordt pas actief als je het bestraalt met licht. Zhou’s nieuwe molecuul is extra efficiënt, aangezien…

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

Promotor: G.P. van Wezel

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Onze gemiddelde leeftijd gaat omhoog en de behoefte naar goede gezondheidszorg wordt steeds groter. Nieuwe medicijnen moeten op de markt komen maar kosten voor de ontwikkeling daarvan moeten omlaag. Tijdens het Medical Delta café op 8 oktober presenteren o.a. dr. Leo Price, dr. Jan de Sonneville en…

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Healthcare Information Systems (HIS) are essential for modern healthcare delivery, yet their development faces significant challenges including heterogeneous data formats, regulatory compliance, and the growing demand for AI-driven decision support.

Onderzoekers in Leiden, onder leiding van Sebastian Pomplun, hebben een nieuwe methode ontwikkeld om honderdduizenden moleculen te screenen voor geneesmiddelenonderzoek — dit keer zonder DNA-tags, maar met massaspectrometrie. ‘We wilden geneesmiddelenonderzoek sneller en toegankelijker maken,’ zegt…

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Promotor: A. Kros

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Hoe kunnen we efficiënte chemische synthese en klinische microbiologie combineren om nieuwe antibiotica tegen Clostridioides difficile-infecties te ontwikkelen?

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Minister Grapperhaus wil inlichtingendiensten bij de opsporing van drugscriminaliteit inzetten. In de inlichtingenwereld bestaan veel aarzelingen over deze wens. Paul Abels, Bijzonder Hoogleraar Governance of Intelligence and Security Services aan het Insitute of Security and Global Affairs (ISGA) spreekt…

Katharina Krüsselmann, promovendus aan het Institute of Security and Global Affairs, sprak bij Omroep Brabant over schietincidenten in Nederland, het onderwerp van haar promotieonderzoek.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange