Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Anticipatie op de uitdagingen en voordelen die AI-ondersteunde beoordelingen met zich meebrengen voor de relatie tussen studenten en docenten, de menselijke, evenals sociaal-economische kosten en kansen die zij voor universiteiten creëren.

Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.

Promotor: K.J. Batenburg

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Promotor: M.L. van Hecke

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

This thesis explores how bees and hoverflies are distributed across the Dutch landscape and how ecological and landscape factors shape their occurrence.

Een internationaal team van astronomen, onder wie drie Leidse sterrenkundigen, hebben een sterrenstelsel ontdekt op een recordafstand van 13,4 miljard lichtjaar. Het stelsel, dat in de richting van het sterrenbeeld Grote Beer staat, is uitzonderlijk helder, waardoor het mogelijk was het op deze recordafstand…

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Hoe verwerken we taal en spraak? Hoe voegen we de informatie op verschillende niveaus – intonatie, zinsstructuur, betekenis, toon, woorden, klanken - samen? Hoe staat de informatie op het ene niveau in verband met informatie op een ander niveau?

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

The complexity of an intelligence problem determines to a great extent the certainty that can be provided by intelligence and security services.

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

Het Leids Universiteits Fonds viert 450 jaar Universiteit Leiden en dat pakken we groots aan!

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Online cursus The Importance and Power of Music in our Society

CONSENT (Consumer sentiment regarding privacy on user generated content services in the digital economy) is a research project funded by the European Union under the 7th Framework Programme. The question central to this research is whether recent changes to consumer and commercial practices developed…

Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…

Het ondersteunen van onderwijsprofessionals in hun doorlopende professionele ontwikkeling zien wij als een belangrijke taak. Voor het leveren van kwalitatief goed onderwijs zijn didactische vaardigheden net zo essentieel als vakkennis. Om dit te ondersteunen bieden wij een breed scala aan trainings-…

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Bekijk op deze pagina eerdere edities van ONZe boekenclub

Het Data Science Onderzoeksprogramma (DSO) combineert Leidse promotieonderzoeken uit allerlei disciplines met data science. Het programma loopt nu ruim twee jaar, en levert verrassende eerste resultaten op. Hieronder vertellen een aantal promovendi over hun ervaringen en hun onderzoek.

How do you engage society to stop biodiversity loss? How do you create political and social involvement to deal with climate change? And how do you balance the economic needs of industry with the negative effects of pollution? If you find these kinds of questions interesting, then this Pre-University…

When you have decided to participate in a Summer School of Leiden University, there are some matters you need to know before arrival. Please take a few minutes to read through the information here to find out what you can do from your side to smooth the process.