Promotor: Prof.dr. A.G.G.M. Tielens

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

Met ingang van 1 april 2018 is Erik Danen benoemd tot hoogleraar Cancer drug target discovery bij het Leiden Academic Centre for Drug Research (LACDR). Zijn vakgebied is celbiologie van kanker, waarin hij zich richt op de achterliggende mechanismen bij uitzaaiingen en resistentie voor behandelingen.

Een jaar lang staat Leiden in het teken van Azië met talloze Aziatische evenementen, conferenties, tentoonstellingen en concerten. Aanleiding is de nieuwe Asian Library van de Universiteit Leiden. Kom lezen, kijken, luisteren, proeven of dansen zoals ze dat doen in Bollywood of Indonesië.

Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal

Op 3 december 2019 verdedigde Meda Couzens haar proefschrift 'The application of the United Nations Convention on the Rights of the Child by national courts'. Het promotieonderzoek is begeleid door promotoren prof.dr. T. Liefaard en prof.mr. J.J. Sloth-Nielsen.

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

In this course, you will explore the organs involved in our food digestion and discover the common causes of abdominal and pelvic pain. The latest graphics and animations will give you new insights and understandings of this part of the body.

The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Het Leiden Asia Year komt eraan. 2017 staat bij de universiteit en in de stad helemaal in het teken van Azië . Heb je ideeën om het programma nog mooier te maken? Meld ze bij de universiteit!

Promotor: A. Achúcarro, Co-Promotor: G.A. Palma

Promotor: K.H. Kuijken

The Sun and all the stars in the night sky reside in the Milky Way galaxy. In the at-rest reference frame of the Galaxy, typical stars travel with velocities of about 100-200 kilometres per second.

Promotor: Prof.dr. M. Ubbink

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

Op de eerste dag van jouw nieuwe baan heb je zweethanden, ben je nerveus en onzeker, maar een paar maanden later zijn die gevoelens al weer verdwenen. Je hebt jouw nieuw rol eigen gemaakt en je bent nu onderdeel van de organisatie. Het proces dat daar naar toe leidt heet

The Role and Effectiveness of the G20. In dit artikel, gepubliceerd in The Changing Global Order onderdeel van the United Nations University Series on Regionalism book series, bespreekt auteur Jaroslaw Kantorowicz de evolutie van de G20.

Promotor: G. van Dijk

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Congres/symposium

The expanding population and economic activity are driving up global energy consumption. Simultaneously, there is an urgent need to transition from fossil fuels to renewable sources to mitigate the climate crisis, primarily caused by fossil fuel combustion.

Arithmetic geometry concerns the number-theoretic properties of geometric objects defined by polynomials. Mathematicians are interested in the rational solutions to these geometric objects.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

Biopolymer sequencing with graphene edge-based tunnel junctions has the potential to overcome current limitations with the third generation of sequencing based on biological nanopores.

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

Promotor: Prof.dr. J. Kuiper

Op 19 december 2019 verdedigde Reza Eftekhar zijn proefschrift 'The Role of the Domestic Law of the Host State in Determining the ratione materiae Jurisdiction of Investment Treaty Tribunals: The Partial Revival of the Localisation Theory'. Het promotieonderzoek is begeleid door promotor prof.dr. E.…

Promotor: A. Achúcarro Co-promotor: A. Boyarsky

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

This thesis explores the theoretical and observational properties of distant massive galaxies that harbour active black holes in their centres and shine brightly at radio wavelengths.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.