This thesis discusses the physical and chemical processes than influence the composition of forming planets.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

Promotores: F.H.J. Redig, W.T.F. den Hollander

Bernet Elzinga (Klinische psychologie) ontvangt met de Vici-beurs uit de Vernieuwingsimpuls van de nationale wetenschapsorganisatie NWO een van de grootste subsidies voor individuele onderzoekers. Deze subsidie heeft ze gekregen voor haar project 'Unravelling the Impact of Emotional Maltreatment on…

Promotor: Prof.dr. E. F. van Dishoeck

Promotor: Richard D. Gill

Tin electrodeposition applications have rapidly evolved in the past 25 years.

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

Zeven Leidse wetenschappers ontvangen een prestigieuze Vici-beurs. Dat maakte de Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) bekend.

Onder vindt u de wetenschappelijke publicaties van het Navigatie Lab Leiden

Traditional hypothesis testing requires researchers to set a fixed sample size in advance. After collecting data, the test determines whether to reject the null hypothesis.

Het onderzoek in dit proefschrift kijkt naar de rol van het locus ceuruleus - noradrenalinesysteem in verscheidene aspecten van menselijke cognitie, en de modulatie van de staat van het brein.

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

In multi/many-core System-on-Chips (SoCs), the performance is almost linearly scaling with the number of processing elements.

Control of infectious diseases poses continuous challenges for human health.

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Internationaal geadopteerde kinderen gebruiken niet meer medicijnen dan hun niet-geadopteerde leeftijdgenoten.

If mankind wants to survive into the 22nd century, we will need to change the way we live drastically. The human impact on our planet is everywhere, we are changing the atmosphere, the oceans and the land, leading to global warming, climate change, loss of biodiversity and pervasive pollution. There…

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

This thesis describes how different colours of light affect various aspects of the growth and development of Arabidopsis and tomato plants⁠.

Promotor: G. J. Kroes

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Dissociative chemisorption is an important reaction step in many catalytic reactions.

Deze serie benadert begrijpend lezen vanuit een cognitief perspectief. We beschrijven hoe lezers tot begrip komen. Dat wil zeggen: hoe zij coherente mentale representaties opbouwen tijdens het lezen van tekst.

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

The database research community has made tremendous strides in developing powerful database engines that allow for efficient analytical query processing.

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

Het onderzoek van de programmagroep Onderwijswetenschappen richt zich op ‘het lerende kind in het onderwijs’. De focus ligt op processen die plaatsvinden tijdens de ontwikkeling en het leren.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Al het onderzoek van de Universiteit Leiden is georganiseerd in instituten. Om recht te doen aan de veelkleurigheid van het onderzoek (en dus ook aan het onderwijs) dat daar uit voortvloeit vindt u op deze pagina’s omschrijvingen van alle Leidse instituten.

Bepaalde ontwikkelingsfases en specifieke problemen van kinderen, zoals somberheid en angsten, vragen om specifieke benaderingen, waar ouders steeds opnieuw vorm aan moeten geven. Hoe wordt onderzoek naar ouderschap en de invloed hiervan op het welzijn van kinderen vormgegeven, en wat valt hiervan te…

This thesis focuses on addressing four research problems in designing embedded streaming systems.