Promotor: Prof.dr. J.N. Kok

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

Promotores: F.H.J. Redig, W.T.F. den Hollander

Bernet Elzinga (Klinische psychologie) ontvangt met de Vici-beurs uit de Vernieuwingsimpuls van de nationale wetenschapsorganisatie NWO een van de grootste subsidies voor individuele onderzoekers. Deze subsidie heeft ze gekregen voor haar project 'Unravelling the Impact of Emotional Maltreatment on…

Promotor: Prof.dr. E. F. van Dishoeck

Human language is constantly evolving with its linguistic structure being shaped by language users at both individual and population levels. Focusing on the interplay between processes of language acquisition and communicative need in shaping human languages, this thesis introduces a novel computational…

Promotor: Richard D. Gill

Tin electrodeposition applications have rapidly evolved in the past 25 years.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

Zeven Leidse wetenschappers ontvangen een prestigieuze Vici-beurs. Dat maakte de Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) bekend.

Traditional hypothesis testing requires researchers to set a fixed sample size in advance. After collecting data, the test determines whether to reject the null hypothesis.

Het onderzoek in dit proefschrift kijkt naar de rol van het locus ceuruleus - noradrenalinesysteem in verscheidene aspecten van menselijke cognitie, en de modulatie van de staat van het brein.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Control of infectious diseases poses continuous challenges for human health.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

In multi/many-core System-on-Chips (SoCs), the performance is almost linearly scaling with the number of processing elements.

Onder vindt u de wetenschappelijke publicaties van het Navigatie Lab Leiden

Het Leiden University Centre for Linguistics (LUCL) heeft een lange traditie in onderzoek naar de talen van de wereld en beschikt over unieke taalkundige expertise. Bij het LUCL helpen we bij het ontwikkelen van interdisciplinaire benaderingen door de interactie tussen datagestuurd en theorie gestuurd…

Internationaal geadopteerde kinderen gebruiken niet meer medicijnen dan hun niet-geadopteerde leeftijdgenoten.

Een collegereeks algemene geologie

Dissociative chemisorption is an important reaction step in many catalytic reactions.

This thesis describes how different colours of light affect various aspects of the growth and development of Arabidopsis and tomato plants⁠.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Deze serie benadert begrijpend lezen vanuit een cognitief perspectief. We beschrijven hoe lezers tot begrip komen. Dat wil zeggen: hoe zij coherente mentale representaties opbouwen tijdens het lezen van tekst.

The database research community has made tremendous strides in developing powerful database engines that allow for efficient analytical query processing.

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Promotor: G. J. Kroes