Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Electron microscopy has become an extremely important techniquein a wide variety of elds.

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Promotor: Prof.dr. P.C. van Welzen

Plastics have become an integral part of modern society due to their versatility and durability.

This collection of papers was compiled in celebration of the remarkable academic career of Professor Wil Roebroeks, who has established himself as one of Europe’s leading figures in Palaeolithic archaeology over the past three decades and founded the Human origins research group at Leiden University…

Lezing, Studium Generale

De Tatiana Afanassjewa-lezingenreeks is een reeks publiekslezingen op woensdagavonden waarvoor iedereen met natuurkundige belangstelling van harte is uitgenodigd.

In deze vuistdikke bundel vertellen meer dan honderd Nederlandse onderzoekers het wereldwijde verhaal van de Nederlandse geschiedenis

De Tatiana Afanassjewa-lezingenreeks is een reeks publiekslezingen op woensdagavonden waarvoor iedereen met natuurkundige belangstelling van harte is uitgenodigd.

The extensive use of electronic communication channels and other devices has opened new possibilities for collecting data on human behavior. This information is sometimes openly accessible, but largely part of administrative registration systems that are not open to the broader public. The data provides…

In this thesis we push the boundaries of high-resolution imaging at radio frequencies between 100 and 200 MHz. Using the International LOFAR Telescope that spans across Europe we achieve sub-arcsecond angular resolution.

Quantum annealing belongs to a family of quantum optimization algorithms designed to solve combinatorial optimization problems using programmable quantum hardware. In this thesis, various methods are developed and tested to understand how to formulate combinatorial optimization problems for quantum…

Promotor: H.J.A. Rottgering, Co-Promotor: R.J. van Weeren

The thesis introduces three methods for high-dimensional prediction problems in the biomedical field. The methods make use of empirical and variational Bayes in the estimation.

In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

Promotor: Prof.dr. M. Ubbink

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Promotores: G.A. Persoon, H.H. de Iongh

Promotor: Prof.dr. G.R. de Snoo

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

The cellular metabolism of immune cells constitutes an important part of their proper function and activation. Using T cells as an example, this phenomenon is highlighted by the metabolic reprogramming that occurs in these cells upon activation.

All the data stored and processed by our computers is encoded as sequences of zeros and ones, called bits. Quantum computers offer an alternative to this traditional way of encoding and manipulating information.

Promotores: G.R. de Snoo, B. Sinsin, Co-Promotor: H.H. de Iongh

This thesis probes under what conditions quantum computing presents an advantage over classical computing.

This thesis investigates the structural evolution and assembly of galaxies since the first few billions years after the big bang.

A Josephson junction is a device where a thin insulating barrier or a nanostructure is placed between two superconducting leads. Such a junction is essential to superconducting qubits that store quantum information due to its anharmonic spectrum.

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

Water is all around us and is vital for all aspects of life. Studying the various compounds and life forms that inhabit natural waters lets us better understand the world around us.

Research

What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?

Learning a programming language is challenging. Even one of the first –but crucial– concepts to learn, variables, is hard to grasp. Variables can represent different roles and functions within a code and need to be named appropriately to support code comprehension and debugging.

The project

In juli 2022 was Leiden gastheer van het ESOF-congres.

Promotores: F.H.J. Redig, W.T.F. den Hollander

In this special edition of Information Polity there is a focus on the transparency challenges of using algorithms in government in decision-making procedures at the macro-, meso-, and micro-levels.

The Sundanese people, the largest ethnic group in West Java, have been using traditional medicine for a long time. Known as ubar kampung, Sundanese indigenous knowledge, beliefs and practices of traditional medicine are based on local people’s knowledge and use of Medicinal, Aromatic, and Cosmetic (MAC)…

Despite their ecological, cultural, and economic importance, lion (Panthera leo) populations in Kenya are declining rapidly due to retaliatory killings following livestock depredation, depletion of wild prey, habitat loss driven by human activities, climate change, and disease.

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