Promotor: Prof.dr. G.P. van Wezel

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

Promotor: Prof.dr. J. Kuiper

Dr. Remko Offringa is met ingang van 1 september 2016 benoemd tot Opleidsingsdirecteur van de masteropleiding Biology. Hij volgt daarmee Johan Memelink op.

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Ontwikkelingen om de mariene biodiversiteit met hoge resolutie te meten, door ernaar te luisteren.

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

Criminologe Marieke Liem is genomineerd voor de verkiezing New Scientist Wetenschapstalent 2015. Stemmen kan tot maandag 7 september.

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Het wemelt van de peilingen in de aanloop naar het Britse referendum op 23 juni. Politicoloog Tom Louwerse over de zin en onzin daarvan. ‘Het is vooral belangrijk hoe de media een partij framen op basis van de polls.’

Promotor: Prof.dr. R.M.H. Merks

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

'Van jongs af aan ben ik bezig te kijken hoe ik iets kan bijdragen aan de wereld', zegt Fleur van Lit, student Geschiedenis en Midden-Oostenstudies. Nu wil ze dat doen door de standpunten van jongeren te bepleiten in de Verenigde Naties. Stem op haar! Dat kan van 23 tot 30 oktober.

Meer leren over het ontstaan van het leven op Aarde? Dat kan in de Summerschool Crises in Biology.

Thomas Bakkum en Tom van der Wel, promovendi bij het Leids Instituut voor Chemisch Onderzoek, winnen poster awards bij de EMBL Chemical Biology Conference 2018 in Heidelberg.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

De tussentijdse verkiezingen in de Verenigde Staten worden een motie van goed- of afkeuring over president Donald Trump en zijn politiek van verdeeldheid, zegt Brendan Carroll, universitair docent Bestuurskunde. In dit blog legt hij uit waarom de opkomst wellicht een beslissende factor wordt.

Bijna alle documenten uit de 16e en 17e eeuw zijn door meerdere personen geschreven, maar staan op naam van één auteur. Nadine Akkerman wil dat rechtzetten met haar onderzoek naar de schrijfklerk.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

The applications of studying the early development of insects range from agriculture to material science.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Prof.dr. Geert de Snoo is per 1 maart bij de Faculteit der Wiskunde en Natuurwetenschappen benoemd tot hoogleraar Conservation Biology. De Snoo blijft hoofd van de gelijknamige afdeling van het Institute of Environmental Sciences (CML).

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Welke briljante bètawetenschapper wordt onze Ontdekker van het Jaar 2019? Wordt het een natuurkundige, bioloog, medicijnontdekker of een astronoom? Of een milieuwetenschapper, wiskundige, chemicus of computerwetenschapper? Stem nu!

In november zijn er Tweede Kamerverkiezingen, maar niet iedereen gaat stemmen. Hoe komt dat, en hoe erg is dat? Internationaal onderzoek naar opkomstpercentages bij verkiezingen werpt nieuw licht op deze vraag – en biedt alternatieven.

Stem voor de Ontdekker van het jaar 2017! Wie van deze onderzoekers verdient volgens jou een prijs voor zijn of haar werk? Vanaf nu kan je stemmen!

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

Scott Waitukaitus is namens LION genomineerd als Discoverer of the Year 2017. Breng snel je stem uit!

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.