This dissertation presents a new perspective on the life, work and character of the Dutch physical chemist Jacobus Henricus van ’t Hoff, first recipient of the Nobel Prize in Chemistry, and one of the most important and colourful scientists in Dutch history. The image of Van ’t Hoff that emerges from…

In this project of the Center for Public Values & Ethics (CPVE) ongoing research is conducted on the history of advice to Dutch central government by so-called State committees from 1814 to 2014. State committees have been installed by Dutch central government since 1814 to provide expert advice, research…

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

Promotor: F.J. van Lunteren, E. Jorin

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

The upscaling of Life Cycle Assessment (LCA) data is recognized as one of the main challenges in the ex-ante LCA of emerging technologies. This challenge arises since industrial-scale system specifications for these technologies are unknown and industrial data is lacking.

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

De Faculteit Geesteswetenschappen biedt plaats aan een verscheidenheid aan gerenommeerde Nederlandse en internationale academici met expertise in een groot aantal vakgebieden die samen bijna alle continenten en periodes beslaan.

The main aim of this project is to reveal and unravel the invisible histories of the UN, transcending the dominant Western perspective to recover the historical agency of Global South actors. The research will investigate how the UN has both facilitated and limited their role in shaping global order…

A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments

Hoe kunnen we op een interdisciplinaire wijze de classificatie van migranten en mensen met een beperking bestuderen en onderzoekers van deze velden samenbrengen om raakvlakken met elkaar te vinden?

This dissertation focuses on investigating the public communication around quantum science and technology that may affect public engagement.

Hoe positioneerde onze academische gemeenschap zich ten opzichte van een systeem dat mensen van hun vrijheid beroofde? Welke rol heeft de universiteit als onderwijsinstelling ingenomen ten opzichte van kolonialisme en het slavernijsysteem? Hoe kunnen wij het beste omgaan met onze bijzondere collecti…

Een internationaal team van onder meer Leidse onderzoekers heeft aangetoond dat er een verfijndere methode is om oude microbiomen te bestuderen. Dat helpt archeologisch onderzoek naar de effecten van Europese kolonisatie in de Caraïben. Publicatie in Nature Scientific Reports op 13 november.

Corinne Hofman, Leids hoogleraar Archeologie van het Caribisch gebied, is gekozen tot lid van de KNAW. ‘Haar werk is origineel en vernieuwend en heeft een grote maatschappelijke relevantie.’

Deze eenjarige Nederlandstalige masterspecialisatie onderzoekt Nederland en zijn mondiale en koloniale context, vanaf de middeleeuwen tot nu.

The thesis is part of a bigger project, the HEPGAME (High Energy Physics Game). The main objective for HEPGAME is the utilization of AI solutions, particularly by using MCTS for simplification of HEP calculations.

Corruption, integrity (or a lack thereof…) and public values are near omnipresent elements in public administration and politics of all times. Cases of corrupt public officials and politicians continuously emerge. Strangely enough, however, it often remains unknown what actually occurred, how something…

In this thesis, single-cell approaches were applied to characterize the impact of aging on the immunological B cell landscape in different models of atherosclerotic cardiovascular disease, with the goal to identify and study new B cell-associated biomarkers and therapeutic targets to halt atherosclerosis…

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

In dit interdisciplinaire onderzoeksprogramma werken onderzoekers uit vijf verschillende disciplines met elkaar samen. Zij stellen zich hieronder (in het Engels) aan u voor.

Bij de Universiteit Leiden krijg je de mogelijkheid om het beste uit jezelf te halen. Heb je tijd en talent? Dan is honoursonderwijs iets voor jou. Of doe een bestuursjaar.

How and to what extent the historic house (re-)constructs identity through image-making in China.

75 jaar na Hiroshima en Nagasaki In samenwerking met Japanmuseum SieboldHuis, naar aanleiding van de tentoonstelling aldaar.

Kunst en vrije tijd, Kunst en vrije tijd

With the dramatic growth of the image data on the web, there is an increasing demand of the algorithms capable of understanding the visual information automatically.

This dissertation explores how Large Language Models (LLMs) can effectively and responsibly contribute to complex decision-making processes. By combining AI and human intelligence, Hybrid Intelligence (HI) emerges, allowing the strengths of both humans and machines to be utilized.

Op 28 oktober 2021 verdedigde Hein van der Bruggen zijn proefschrift en behaalde daarmee de doctorstitel.

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

Overzicht van de belangrijkste papyrologische websites

In deze bundel wordt verslag gedaan van onderzoek op het gebied van duurzaamheid, uitgevoerd aan de Leidse rechtenfaculteit.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen)

Promotores: F.H. van Lunteren, F.P. Israel

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Where does the urge to collect come from? What are the explicit or underlying reasons for gathering large amount of objects?

Promotores: G. Persoon, R. Schefold