Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

Promotores: P.G.L. Klinkhamer, P.M. Brakefield, Co-Promotor: M. Bruinsma

In the first part of this thesis we study the geometry of folding patterns.

Human language is constantly evolving with its linguistic structure being shaped by language users at both individual and population levels. Focusing on the interplay between processes of language acquisition and communicative need in shaping human languages, this thesis introduces a novel computational…

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

Empirical Legal Studies in Leiden focuste op het bouwen van een interdisciplinaire gemeenschap van rechtsgeleerden en sociale wetenschappers die samen juridische vraagstukken onderzochten op het snijpunt van recht en gedrag, waarbij diverse soorten methoden werden gebruikt.

Welke rol spelen stress en angst bij de vorming van nocebo hyperalgesie?

This thesis investigates innovative and classical strategies in glycoconjugate vaccine development to address the growing threat of multidrug-resistant bacterial infections.

This thesis describes how to scale down concepts of macroscopic mechanical metamaterials to the thermal scale using a system of flexibly-linked colloids.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Metal-organic compounds hold great promise as photoactivated chemotherapy (PACT) agents, leveraging their unique geometric and electronic properties to achieve precise spatiotemporal control over drug activation.

Simon Portegies Zwart, hoogleraar Computationele Sterrenkunde, gebruikt de rekenkracht van computers om de evolutie van sterren te simuleren. We praten met hem over zijn vakgebied en over de uitdagingen van het werken met enorme hoeveelheden complexe data.

De Nederlandse Onderzoekschool voor Astronomie krijgt twee nieuwe directieleden. Ronald Stark (nu nog werkzaam bij NWO) is per 1 september de nieuwe uitvoerend directeur van NOVA. Amina Helmi (hoogleraar Dynamica, structuur en vorming van de Melkweg aan het Kapteyn Instituut van de Rijksuniversiteit…

Na jaren van ontwikkeling is het moment eindelijk daar: een enorme cryostaat, een bijzonder geavanceerde vriezer die de gevoelige onderdelen extreem koud houdt, is vanuit Zürich in Leiden aangekomen. Het apparaat is het grootste onderdeel van METIS, een van de eerste instrumenten op ESO’s Extremely…

Lezing, LIMS seminar

De zoektocht naar leven elders in het heelal is weer een stapje verder, dankzij de Leidse astrofysicus Matteo Brogi. In zijn proefschrift, waarop hij cum laude promoveerde, demonstreert hij een nieuwe methode om verre planeten te onderzoeken.

Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Hoe verwerken we taal en spraak? Hoe voegen we de informatie op verschillende niveaus – intonatie, zinsstructuur, betekenis, toon, woorden, klanken - samen? Hoe staat de informatie op het ene niveau in verband met informatie op een ander niveau?

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

Promotor: Prof.dr. G.J. Kroes

This thesis surveys the intersection of computed tomography (CT) and machine learning (ML), treating CT as an ill-posed inverse problem shaped by object properties, imaging physics, and data limitations.

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

Beneficial plant-associated microbiota, particularly those inhabiting the rhizosphere, contribute substantially to plant health through pathogen suppression, stimulation of plant defence responses, and enhanced nutrient acquisition.

Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.

Cursus, Workshop

Na 30 dagen hard werken is de experimentele replica van de ijzertijdkano van Vlaardingen Vergulde Hand klaar! Vlaardingse schoolkinderen zullen de kano op 16 februari te water laten.

Het is de grootste database voor ruimte-ijs ooit: De Leiden Ice Database for Astrochemistry: LIDA. LIDA is gemaakt door astrofysici van de Leidse Sterrewacht en omvat niet alleen honderden meetgegevens, maar ook programma’s om astronomische waarnemingen te onderzoeken en nieuwe metingen met de James…

Astronomen willen het heelal begrijpen, van de Oerknal tot nu, en hoe dit verder zal gaan. In Leiden concentreren ze zich daarbij op twee vragen: 'Hoe ontstaan sterren en planeten? en 'Hoe ontstonden in het jonge heelal sterrenstelsels en zwarte gaten?' Een nieuwe generatie telescopen – net klaar of…

In de AD-rubriek de 'Zomeruniversiteit' vertellen de knapste koppen van Nederland over de ontwikkelingen in hun vakgebied. Deze week was de beurt aan hoogleraar Moleculaire astrofysica Ewine van Dishoeck.

Onderwijs omvat wiskunde, informatica en data science, astrofysica, natuurkunde, chemie tot bio-farmaceutische wetenschappen, biologie en milieukunde.

De onderzoeksgroep Corporate Governance en Strategie onderzoekt hoe, met wie en voor wie een onderneming waarde creëert/vastlegt, met als doel de praktijk en beleidsmakers te informeren over kwesties rondom bestuur. De onderzoeksgroep focust zich op het duale karakter van de onderneming. Namelijk als…