Promotor: A.W. van der Vaart

This thesis mainly extends the theory of positive operators on Riesz spaces to a setting of pre-Riesz spaces.

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The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

In this thesis three different topics in number theory are studied.

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

Promotor: H.W. Lenstra

Promotors: Prof.dr. J. Zaanen, Prof.dr.ir. H. Hilgenkamp

Bekijk de aanmelding- en toelatingsprocedure voor Political Theory: Legitimacy and Justice (MSc) aan Universiteit Leiden: vereiste bacheloropleiding, aantal ECTS, en eventuele taal‑ of portfolio-eisen.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Promotores: J.C. van Houwelingen, S.A. van de Geer

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

The applications of studying the early development of insects range from agriculture to material science.

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Promotor: Prof.dr. B. van de Water

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

In this thesis, we show that we can use Shimura’s CM theory to explicitly compute the Hilbert class field of any primitive quartic CM field.

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Bekijk de toelatingseisen voor de MSc Nederlandse Politiek aan Universiteit Leiden: vereiste bacheloropleiding, academische credits en taalvaardigheidseisen.

Promotor: F. Arbab

Op 1 april 2020 verdedigde Marc Broekema zijn proefschrift 'Cognitive Bias in the Judgment of Business Valuations and Valuators'. Het promotieonderzoek is begeleid door promotor prof. dr. J.I. van der Rest.

This dissertation is organised into three parts, each addressing a distinct research area related to Gibbs measures.