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891 zoekresultaten voor “gene theory” in de Publieke website

• Coherent dynamics in solar energy transduction Onderzoeksoutput

  Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

• Fermions and Bosons: Excitons in strongly correlated materials Onderzoeksoutput

  Promotors: Prof.dr. J. Zaanen, Prof.dr.ir. H. Hilgenkamp

• Diophantine equations in positive characteristic Onderzoeksoutput

  In this thesis three different topics in number theory are studied.

• Basis reduction for layered lattices Onderzoeksoutput

  Promotor: H.W. Lenstra

• A chemical biology approach to explore lipid metabolism in neurological disorders Onderzoeksoutput

  Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

• Modulation of leukocyte homeostasis in atherosclerosis Onderzoeksoutput

  Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

• Nucleosome stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy Onderzoeksoutput

  In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

• Another Brick in the Wall: The role of the actinobacterial cell wall in antibiotic resistance, phylogeny and development Onderzoeksoutput

  Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

• Innovative strategies to clinically characterize the human tear proteome Onderzoeksoutput

  Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

• Linking soil microbial community dynamics to N2O emission after bioenergy residue amendments Onderzoeksoutput

  Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

• Mechanical and genetics basis of cellularization and serosal window closure in Tribolium castaneum Onderzoeksoutput

  The applications of studying the early development of insects range from agriculture to material science.

• Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier Onderzoeksoutput

  Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

• Image-based phenotypic screening for breast cancer metastasis drug target discovery Onderzoeksoutput

  The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

• Unraveling the mechanism of multicopper oxidases: from ensemble to single molecule Onderzoeksoutput

  Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

• Algorithms for the description of molecular sequences Onderzoeksoutput

  Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

• Toll-like receptor signaling in the innate immune system of zebrafish larvae Onderzoeksoutput

  Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

• Unfolding the regulation of stress response pathways upon liver injury Onderzoeksoutput

  Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

• Uncovering vulnerabilities in triple-negative breast cancer Onderzoeksoutput

  Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

• Statistical methods for microarray data Onderzoeksoutput

  Promotores: J.C. van Houwelingen, S.A. van de Geer

• The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus Onderzoeksoutput

  Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

• Carcinogenicity of insulin analogues Onderzoeksoutput

  Promotor: Prof.dr. B. van de Water

• Comparative genomics of the balanced lethal system in Triturus newts Onderzoeksoutput

  All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

• Structural changes in single chromatin fibers induced by tension and torsion Onderzoeksoutput

  Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort

• Evolution and development of flowers, fruits and inflorescences of Phalaenopsis and other orchid species Onderzoeksoutput

  The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

• The Ecology and Evolution of Microbial Warfare in Streptomyces Onderzoeksoutput

  The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

• Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors Onderzoeksoutput

  Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

• Ecology and genomics of Actinobacteria and their specialised metabolism Onderzoeksoutput

  Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

• Disrupting the transcriptional machinery to combat triple-negative breast cancer Onderzoeksoutput

  Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

• Stress-induced protein dynamic and growth arrest in C. elegans during development Onderzoeksoutput

  During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

• Genetic and environmental factors determining heterogeneity in preservation stress resistance of Aspergillus niger conidia Onderzoeksoutput

  Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

• Controlling growth and morphogenesis of the industrial enzyme producer Streptomyces lividans Onderzoeksoutput

  Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

• Inhibitors and probes targeting PslG Onderzoeksoutput

  Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

• 
  Jan Vonk Hoogleraar Wiskunde

  Wiskunde en Natuurwetenschappen

• Compressed Σ-Protocol Theory Agenda - 1 juni 2023

  Promotie

• Complex multiplication constructions of abelian extensions of quartic fields Onderzoeksoutput

  In this thesis, we show that we can use Shimura’s CM theory to explicitly compute the Hilbert class field of any primitive quartic CM field.

• Toelatingseisen Nederlandse politiek (MSc)

  Bekijk de toelatingseisen voor de MSc Nederlandse Politiek aan Universiteit Leiden: vereiste bacheloropleiding, academische credits en taalvaardigheidseisen.

• 
  Tim Verdoes Universitair docent

  Faculteit Rechtsgeleerdheid

• Characterization of candidate genes in unexplained polyposis and colorectal cancer Agenda - 28 november 2023

  Promotie

• T-cell gene therapy for low mutational burden cancer Agenda - 9 januari 2025

  Promotie

• Targeting tumors using T-cell receptor gene transfer Agenda - 30 november 2023

  Promotie

• Viral gene therapy approaches for CRB1 retinal disease Agenda - 2 november 2023

  Promotie

• 
  Steven David Pre-PhD kandidaat

  Faculteit Governance and Global Affairs

• Approach to Markov Operators on Spaces of Measures by means of equicontinuity Onderzoeksoutput

  The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.

• Gibbs States in Statistical Mechanics and Dynamical Systems Onderzoeksoutput

  This dissertation is organised into three parts, each addressing a distinct research area related to Gibbs measures.

• On electronic signatures of topological superconductivity Onderzoeksoutput

  Promotor: Prof.dr. C.W.J. Beenakker

• X-ray spectroscopy of interstellar dust: from the laboratory to the Galaxy Onderzoeksoutput

  In this thesis, we present new laboratory data of interstellar dust analogues.

• ALGANT Onderzoeksproject

  Fundamental research in the ALgebra, Geometry And Number Theory

• Enhanced coinduction Onderzoeksoutput

  Promotores: Prof.dr. F.S. de Boer, Prof.dr. J.J.M.M. Rutten (Radboud Universiteit Nijmegen)

• Groups and fields in arithmetic Onderzoeksoutput

  Promotor: Prof.dr. H.W. Lenstra

• Automata-theoretic protocol programming Onderzoeksoutput

  Promotor: F. Arbab