Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Promotor: Prof.dr. J. Kuiper

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

I have studied the hot, diffuse gas around and between galaxies. Specifically, I have used the EAGLE numerical simulations of galaxy formation to predict the properties of this gas, and I have used those properties to predict specific observables: soft X-ray absorption and emission lines.

Surface plasmons (SPs) are surface waves at the interface between a dielectric and a good metal, and are formed by the interaction between light and the free electrons at the metal-dielectric interface. They provide strong field confinement for optical fields, opening new possibilities for enhanced…

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

De onderzoeksgroep Organizational & Entrepreneurial Behavior onderzoekt het gedrag van individuen en groepen die in organisaties werken, organisaties starten, of organisaties leiden, met als doel om organisatorische praktijken te informeren. Door zich te concentreren op het gedrag van (groepen) werknemers,…

In januari starten negentien MOOCs van de Universiteit Leiden. Iedereen kan gratis deelnemen aan deze online cursussen, die variëren van terrorismebestrijding tot niertransplantatie.

Gamic Learning in East Asian Studies - Wat kunnen spellen ons vertellen over de manier waarop mensen leren?

Felienne Hermans, universitair hoofddocent bij informatica gaat didactische strategieën van tweedetaalonderwijs toepassen op programmeeronderwijs.

Ontwikkeling veldonderwijs en aansluiting bij de beroepspraktijk

Op weg naar een framework voor wiskundig denken waarin vakinhoud en wiskundige denkactiviteiten zijn geïntegreerd

Ontwikkeling van digitale toetsing.

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This study tests whether behavioural problems at a young age are related to early reading and mathematics development.

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Workshop

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Workshop

Kunst en vrije tijd, Kunst en vrije tijd

De programmagroep Onderwijswetenschappen verzorgt onderwijs op het gebied van onderwijs, het leren en de ontwikkeling van leerlingen in de schoolcontext. Studenten worden aangemoedigd uitkomsten van wetenschappelijk onderzoek te gebruiken om hun mening over het onderwijsbeleid en de onderwijspraktijk…

De programmagroep Leer- en Gedragsproblemen in het Onderwijs is verantwoordelijk voor onderwijs op het gebied van leerproblemen binnen de bachelor- en masteropleidingen van het Instituut Pedagogische Wetenschappen.

Hifadhi ya Dijiti ya Ustadh Mau

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Promotor: Prof. dr. A.G.G.M. Tielens

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

Automated Machine Learning (AutoML) is widely used to automatically build a suitable practical Machine Learning (ML) model for an arbitrary real-world problem, reducing the effort of practitioners in the ML development cycle for real-world applications. Optimization is a key part of a typical AutoML…

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…