BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Promotor: T.H. Oosterkamp

This book is a first comparative study of the Nuni dialects.

Promotores: H.W. Lenstra, A. Lucchini

In the near future oral polio vaccine (OPV) will be replaced by inactivated polio vaccine (IPV) as part of the eradication program of polio. For that reason, there is a need for substantial amount of safe and more affordable IPV for low-income countries. Bioneedles, which are biodegradable mini-implants,…

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…

Promotor: Prof.dr. J. den Hertog

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

The aim of this research was to develop an effective, generative, and practical approach to enhance students’ structure-property reasoning (SPR).

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

Modern receptions of Graeco-Roman Antiquity are important ideological markers of the ways we envisage our own twenty-first-century societies. An urgent topic of study is: what kinds of narratives – sometimes controversial – about Antiquity do people create for themselves at this moment in time, and…

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

LUCIS produces various video series and MOOCs to showcase the variety of expertise available at Leiden University.

Promotor: Prof.dr. M.K. Richardson, Co-Promotor: F. Witte

A Persistent Revolution: History, Nationalism, and Politics in Mexico since 1968

This dissertation reports on the pedagogical content knowledge (PCK) of science teachers during a professional development program. This research intended to help us understand why and how teachers make their classroom decisions as they teach science.

Summary

Promotor: Prof.dr. P. Stevenhagen, Co-promotor: Prof. dr. B. de Smit

Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

On the 20th of June, Camil Staps successfully defended a doctoral thesis. Leiden University Centre for Linguistics congratulates Camil on this achievement!

The aim of this dissertation is to provide insight in interethnic prejudice of children in the Netherlands and attitudes and ideologies that they are exposed to through two socialization agents (parents and children’s books).

This dissertation focuses on the production and consumption of a mediation show in China that collaborates with the local Justice Bureau and broadcasts on an entertainment channel—exploring answers to questions raised from the mentioned entertainisation, social and political, and cultural issues.

Unfolding potential

The vegetative growth period for leafy vegetables like lettuce is essential for yield and quality.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Leiden University joind in the second edition of the Impact Fair. This was for anyone who wants to contribute to the world of tomorrow and is seeking inspiration.

Alumni event, Arts and Culture

In this thesis, single-cell approaches were applied to characterize the impact of aging on the immunological B cell landscape in different models of atherosclerotic cardiovascular disease, with the goal to identify and study new B cell-associated biomarkers and therapeutic targets to halt atherosclerosis…

Urbanisation is steadily increasing with estimates expecting that 68% of the global population will live in cities by 2050. To accommodate the rural to urban transition, large quantities of land are transformed from natural to urban lands.

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest common cancer, with only 8% of patients surviving for five years. One reason for this poor outcome is that current chemotherapy treatments are highly toxic, often leaving patients too sick to receive treatment or forcing doctors to lower the dose…

Nature, nurture and neural mechanisms of social emotion regulation in childhood

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

S.S. Kolipaka’s thesis questions and investigates the survival prospects of reintroduced tigers and their offspring’s in the human dominated landscape of Panna tiger reserve in India.

Up to 50% of individuals with Parkinson's disease develop cognitive impairment over time; this study explores the use of 'practice effects' on neuropsychological tests as an early predictor of cognitive decline.

On 12 November 2019, Larissa Koupriuchina defended her thesis 'Judgmental Adjustments in Revenue Management'. The doctoral research was supervised by Prof. J.I. Van der Rest.

Combining cutting-edge quantitative approaches with more traditional book history approaches, this new book offers the first history of medieval manuscript destruction in England from the medieval period to the present.

How Perceived (In)Visible Dissimilarity Relates to Feelings of Inclusion at Work

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On the 27th of February, Marta Morgado successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Marta on this achievement!

This research tries to create a coherent comprehension of misfit, enhance conceptual knowledge, highlight prevalent knowledge.

In 'The Spirit of Matter', Peter Pels explores the significance of emotionally evocative objects, challenging the denial of their existence in modern 'mind over matter' ideology.

Light obscuration (LO) is the current standard technique for subvisible particle analysis in the quality control of parenterally administered drugs, including therapeutic proteins.

Evert Jan van Leeuwen’s entry in Auteur Press’s Devil's Advocate series provides a complete study of the aesthetic appeal of Roger Corman's influential first Poe picture House of Usher.

What is the effect of transgovernmental networks on the principles and practices of democratic accountability within national central governments?