Dit proefschrift gaat over theoretische oppervlakte chemie binnen het veld van de heterogene katalyse.

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.

Shahin Nasiri (28), MA-student Filosofie aan de Universiteit Leiden en afkomstig uit Iran, heeft de Peter Baehr Prijs 2014 gewonnen met zijn onderzoeksvoorstel “Rethinking the notion of freedom from the standpoint of the refugee”. Veelbelovend is de voorgestelde methodologie om filosofische kritieken…

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Dr. Marcellus Ubbink is dit voorjaar bij de Faculteit Wiskunde en Natuurwetenschappen benoemd tot hoogleraar Protein Chemistry. Ubbink kreeg in 2008 een Vici-subsidie van NWO.

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

Lezing

Lezing

Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…

Naast de 2 TOP grants heeft het LIC ook nog 4 ECHO’s binnengehaald voor dr. Francesco Buda, professor Gijs van der Marel met Jeroen Codée, dr. Dmitri Filippov en professor Gilles van Wezel.

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

This thesis introduces the concept of

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

Ethische toetsing gaat onder andere over de bescherming van de onderzoeksparticipanten en onderzoekers en die bescherming is gelijk ongeacht wie het onderzoek uitvoert. Pedagogische Wetenschappen onderwijst studenten in de ethische aspecten van onderzoek doen.

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Prof. A.G.G.M. (Xander) Tielens wordt bij 1 januari bij de Faculteit der Wiskunde en Natuurwetenschappen benoemd tot hoogleraar ‘Physics and Chemistry of the Interstellar Medium’. Tielens werkt momenteel als senior onderzoeker bij Ames in Moffett Field, Californië. Ames is een onderdeel van NASA. Daarnaast…

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

‘We moeten oppassen dat respect voor politiek pluralisme niet leidt tot het accepteren van een essentialistisch verschil tussen “West” en “Oost” als het aankomt op menselijke waardigheid,’ waarschuwt universitair docent Casper Wits in NRC.

Corruption, integrity (or a lack thereof…) and public values are near omnipresent elements in public administration and politics of all times. Cases of corrupt public officials and politicians continuously emerge. Strangely enough, however, it often remains unknown what actually occurred, how something…

Op 1 oktober 2019 is het startsein gegeven voor het accreditatietraject van de Executive Master Legal Technologies. Dit masterprogramma wordt ontwikkeld en uitgevoerd in een samenwerking tussen de faculteiten FGGA, Rechtsgeleerdheid en Wiskunde en Natuurwetenschappen (LIACS en MI).

In this project of the Center for Public Values & Ethics (CPVE) ongoing research is conducted on the history of advice to Dutch central government by so-called State committees from 1814 to 2014. State committees have been installed by Dutch central government since 1814 to provide expert advice, research…

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

In samenwerking hebben eLaw en het Design for Values Institute van de TU Delft een onderzoeksproject afgerond over “Artificiële Intelligentie en Ethiek bij de Nederlandse Politie”. Hierin zijn een whitepaper over verantwoord gebruik van AI bij de politie en een langetermijn strategie opgeleverd.

De afdeling Beleid en Innovatie van het Instituut Bestuurskunde richt zich op het vormgeven, implementeren en evalueren van beleid met innovatieve benaderingen. Ons doel is om complexe maatschappelijke uitdagingen aan te pakken door technologische vooruitgang en creatieve beleidsinstrumenten te onde…

FAIR-ASSESS wordt bijgestaan door een wetenschappelijke raad bestaande uit interne leden verbonden aan Universiteit Leiden en externe leden van buiten de universiteit met expertise in het veld.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.

Artificiele Intelligentie en Ethiek bij de Politie

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.